In the process, the bodys adaptive defense system can help the body resist damage through detoxification and excretion of these carcinogens by regulating the absorption and metabolism of these carcinogens.Wynk Music brings to you Sefapanong Ke Bohang MP3 song from the movie/album Difela Tsa Sione. These carcinogens can bind to DNA and form DNA-adducts, which can further damage DNA if not repaired and thus induce genomic instability as well as mutations in some cancer-related genes.īoth would contribute to the susceptibility and development of human cancers 4, 5. Tobacco contains several well-established chemical carcinogens, such as polycyclic aromatic hydrocarbons (PAHs), tobacco-specific nitrosamines, and metals 3. Meanwhile, the number is on the increase and will cause heavy social burdens with respect to the large number of smokers in China.
We genotyped three putatively functional SNPs of PXR ( i.e., rs3814055CT, rs3732360CT, and rs3814058CT) and analyzed their associations with lung cancer risk in a two-stage case-control study with a total of 1559 lung cancer cases and 1679 controls in the southern and eastern Chinese population. The aim of the current study was to investigate whether the single nucleotide polymorphisms (SNPs) of PXR could alter lung cancer susceptibility in Chinese by affecting the function or expression of PXR. Low PXR expression has been shown to promote tumor initiation and metastasis. Pregnane X receptor (PXR) is an important member of the nuclear receptor superfamily that copes with various endobiotic and xenobiotic stimuli, such as carcinogens by regulating an array of environmental response genes. Received: Revised: 17 June 2014 Accepted: 6 August 2014 Published: 29 September 2014. Visit our dedicated information section to learn more about MDPI.Ī Functional Polymorphism in the 3-UTR of PXR Interacts with Smoking to Increase Lung Cancer Risk in Southern and Eastern Chinese Smoker. Please let us know what you think of our products and services. Abigail mac collection torrentįind support for a specific problem in the support section of our website. Journal of Theoretical and Applied Electronic Commerce Research (JTAER). Journal of Otorhinolaryngology, Hearing and Balance Medicine (OHBM). Journal of Open Innovation: Technology, Market, and Complexity (JOItmC). International Journal of Turbomachinery, Propulsion and Power (IJTPP).
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